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. 2020 Jun 1;11:2722. doi: 10.1038/s41467-020-16598-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Comparison of Tiled-C and Hi-C contact matrices at 2 kb resolution in mouse ES cells. Contact frequencies represent normalized, unique interactions in three and four replicates for Tiled-C and Hi-C data, respectively. Coordinates (mm9): chr11:29,902,000–33,228,000. b Tiled-C contact matrices of ~3.3 Mb spanning the mouse α-globin locus in primary mature erythroid cells (top) and ES cells (bottom) at 2 kb resolution. Contact frequencies represent normalized, unique interactions in three replicates. Gene annotation (α-globin genes highlighted in red), open chromatin (ATAC), and CTCF occupancy are shown below the matrices. Coordinates (mm9): chr11:29,902,000–33,228,000. c Tiled-C contact matrices of ~3.4 Mb spanning the mouse Sox2 locus in primary mature erythroid cells (top) and ES cells (bottom) at 5 kb resolution. Contact frequencies represent normalized, unique interactions in four replicates. Gene annotation (Sox2 gene highlighted in red), open chromatin (ATAC), and CTCF occupancy are shown below the matrices. Coordinates (mm9): chr3:33,200,000–36,565,000.