Table 1.
Homologs of autophagy-related genes.
| S. cerevisiae | Mammals | ||||||
|---|---|---|---|---|---|---|---|
| ULK1 complex | Atg1 | ULK1 | ULK2 | ULK3 | ULK4 | ||
| Atg13 | ATG13 | ||||||
| Atg17 | FIP200 | ||||||
| – | ATG101 | ||||||
| PI3K complex | VPS34 | VPS34 | |||||
| VPS15 | VPS15 | ||||||
| Atg6 | Beclin 1 | ||||||
| Atg14 | ATG14 | UVRAG | |||||
| – | Ambra1 | ||||||
| – | Rubicon | ||||||
| PI3P-binding proteins | Atg18 | WIPI1 | WIPI2 | WIPI3 (WDR45B) | WIPI4 (WDR45) | ||
| ATG9 vesicles | Atg9 | ATG9L1 | ATG9L2 | ||||
| LC3 conjugation system | Atg8 | LC3A | LC3B | LC3C | GABARAP | GABARAPL1 | GABARAPL2/GATE-16 |
| Atg4 | ATG4A | ATG4B | ATG4C | ATG4D | |||
| Atg3 | ATG3 | ||||||
| Atg7 | ATG7 | ||||||
| Atg10 | ATG10 | ||||||
| Atg5 | ATG5 | ||||||
| Atg12 | ATG12 | ||||||
| Others | Atg2 | ATG2A | ATG2B |