Table 3.

Effect of aging on the JAK1, STAT3, SOCS3, TNFα, GSH and MDA in all groups.

	Adult Mean ± SD	Early senile Mean ± SD	Late senile Mean ± SD	P value
JAK1	1.02 ± 0.014	0.96 ± 0.033	0.21 ± 0.011	Early senile versus adult p = 0.001** Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**
STAT3	0.86 ± 0.018	0.84 ± 0.032	0.17 ± 0.014	Early senile versus adult p > 0.05NS Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**
SOCS3	0.47 ± 0.018	0.51 ± 0.054	0.96 ± 0.018	Early senile versus adult p > 0.05NS Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**
TNFα	45.23 ± 0.16	79.08 ± 15	110.28 ± 0.23	Early senile versus adult p < 0.001** Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**
GSH	38.25 ± 0.18	31.85 ± 0.52	17.25 ± 0.18	Early senile versus adult p < 0.001** Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**
MDA	29.25 ± 0.18	32.71 ± 0.76	76.04 ± 0.091	Early senile versus adult p < 0.001** Late senile versus adult p < 0.001 ** Late senile versus early senile p < 0.001**

SD: standered deviation; NS: Non significant (p > 0.05); ^#statistically significant (p ≤ 0.05); **statistically highly significant (p ≤ 0.001).