Table 1.
Particle size, PDI and potential of CSL-NSps prepraed using different stabilizers and at different drug-carrier ratio (n = 3).
| Stabilizer | Drug: stabilizer |
Dh (nm) | PDI | Zeta (mV) | Stabilitya | DLC % |
|---|---|---|---|---|---|---|
| TPGS | 1:1 | 119.0 ± 2.46 | 0.20 ± 0.04 | -9.44 ± 0.52 | <4 weeks | b |
| mPEG2k-PCL2k | 1:1 | 126.0 ± 1.94 | 0.23 ± 0.03 | -10.2 ± 0.47 | <4 week | b |
| Sodium oleate | 1:1 | 181.1 ± 1.12 | 0.13 ± 0.02 | -51.6 ± 0.35 | <4 weeks | b |
| P-188 | 1:1 | 140.8 ± 1.17 | 0.14 ± 0.04 | -18.8 ± 0.35 | > 4 weeks | 48.70 |
| P-188 | 5:1 | 146.5 ± 3.16 | 0.11 ± 0.08 | -19.9 ± 0.59 | > 4 weeks | 81.92 |
| P-188 | 8:1 | 147.9 ± 2.16 | 0.12 ± 0.02 | -19.2 ± 0.32 | > 4 weeks | 86.83 |
aStorage stability at 4 °C, meaning similar particle sizes and no aggregation;
bThe data were not measured.