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. 2020 Jun 1;9(5):58. doi: 10.1038/s41389-020-0241-0

Fig. 6. PNO1 promotes LUAD tumorigenesis in vivo.

Fig. 6

a Images of tumors from nude mice in the sh-Ctrl and sh-PNO1 groups. b, c Tumor weights and volumes in the two groups. *P < 0.05, **P < 0.01, ***P < 0.001. d The protein level of PNO1, EMT markers and Notch intracellular domains in established xenograft model assessed by Western Blotting. e H&E staining about lung metastasis of tail vein injected mice, 4× and 40×. f The numbers of lung metastasis nodules in sh-Ctrl and sh-PNO1 group. g A proposed mechanistic scheme for PNO1 regulated by miR-340-5p induced lung adenocarcinoma proliferation and metastasis through Notch pathway.