Table 1.

Composition of TLSs and detection of markers

	Structure/cell	Corresponding marker
Most common TLS content	High endothelial venules Dendritic cells B cells T cells	No specific marker, MECA-79 DC-LAMP CD20 CD3
Possible components of TLSs	Germinal centers Proliferating B cells T follicular helper cells	Ki67 Ki67 CD4, CXCR5, CD40L, IL21, IL6
Other markers associated with TLSs	Chemokines Cytotoxic T cells T regulatory cells Endothelial cells Follicular DCs, mature B cells	CCL-2,3,4,5,8,18,19,21 CXCL-9,10,11,13 CD8 FOXP3 CD31 CD23