Table 3.

How may TLS be of use in the clinical environment?

TLS feature	Clinical application	Barrier to clinical uptake
High TLS numbers are associated with a positive patient prognosis in many cancers.	A more accurate prognosis will assist with better patient selection for treatments.	There is mixed evidence for prognostic ability based on the frequency of TLS alone. There is no evidence yet that TLS provide prognostic information over and above that provided by existing validated tools.
Subtypes of TLS features are associated with differing patient outcomes.	Better characterization of TLS subtype features may assist with patient selection for existing immunotherapies and developing new therapies.	Multiplex characterization of TLS is an ongoing research area.