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. 2020 May 4;30(6):465–474. doi: 10.1038/s41422-020-0324-7

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© Center for Excellence in Molecular Cell Science, CAS 2020

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Fig. 2 — a Super enhancers (SEs) defined as genomic regions with dense clustering of highly active enhancers accompanying strong activation-linked histone modification (such H3K27ac), promoted open chromatin states, strong binding of multiple transcription factors, and increased DNA demethylation. They contribute to the cell-type specific gene expression and cell lineage determination. b Treg-specific SEs are associated with Treg signature genes.