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. 2020 May 4;30(6):465–474. doi: 10.1038/s41422-020-0324-7

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© Center for Excellence in Molecular Cell Science, CAS 2020

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Fig. 5 — Characterization of specific demethylated regions in the genome of naïve or activated Treg or Tconv cells reveals that SNPs associated with autoimmune disease (e.g., SNPs found at IL2RA or CTLA4 gene loci) are predominantly present at naïve Treg-specific DRs. Black and white circles represent methylated and demethylated CpGs, respectively.