Table 2.
Efficacy and Safety Outcomes.
| Efficacy Outcomes | |||
|---|---|---|---|
| Efficacy Outcome | Number of Studies Reporting the Outcome | Mean Change (95% Confidence Interval) | Estimate of Heterogeneity (I2) |
| Balloon Pulmonary Angioplasty | |||
| 6-Minute Walk Distance, meters | 11/11 | 71.0 (47.4–94.5) | 70.5% |
| Cardiac Index, L/min/m2 | 10/11 | 0.2 (0.1–0.4) | 60.3% |
| Mean Pulmonary Artery Pressure, mmHg | 10/11 | −14.8 (−18.2 to −11.5) | 83.6% |
| PVR, Wood units | 10/11 | −3.1 (−4.9 to −1.4) | 95.2% |
| Pulmonary Vasodilators | |||
| 6-Minute Walk Distance, meters | 23/23 | 47.8 (34.5–61.2) | 94.4% |
| Cardiac Index, L/min/m2 | 13/23 | 0.3 (0.2–0.4) | 46.1% |
| Mean Pulmonary Artery Pressure, mmHg | 11/23 | −4.9 (−6.9 to −2.8) | 78.2% |
| PVR, Wood units | 12/23 | −1.6 (−2.4 to −0.8) | 73.1% |
| Safety Outcomes | |||
| Safety Outcome | Number of Studies Reporting the Outcome | Point Estimate of Incidence (95% Confidence Interval) | Estimate of Heterogeneity |
| Balloon Pulmonary Angioplasty | |||
| All-Cause Mortality | 8/11 | 3.4% (2.0–4.9%) | 0.0% |
| Reperfusion Pulmonary Edema | 8/11 | 12.9% (7.7–18.2%) | 91.0% |
| Wire Injuries | 6/11 | 5.3% (3.3–7.2%) | 60.6% |
| Pulmonary Vasodilators | |||
| Outcomes | Number of Studies Reporting the Outcome | Point Estimate of Incidence (95% Confidence Interval) | Estimate of Heterogeneity |
| All-Cause Mortality | 20/23 | 1.3% (0.1–2.3%) | 16.0% |
| Serious Adverse Events | 19/23 | 9.6% (4.7–14.6%) | 90.2% |