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. 2020 May 26;11:464. doi: 10.3389/fphys.2020.00464

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Copyright © 2020 Kappadan, Telele, Uzelac, Fenton, Parlitz, Luther and Christoph.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Deceleration of VF by Blebbistatin and acceleration of VF after washout demonstrating reversibility of decelerating effect of Blebbistatin. The frequency and complexity of the electrocardiogram (shown) and optical traces measured during VF decreases with Blebbistatin (here 1.4μM after 15 min) and increases after washout of Blebbistatin (100 min), respectively. (B) Frequency decrease after administration of Blebbistatin (from 15.3 ± 3.2Hz to 9.6 ± 0.8Hz, data from N = 1 heart) to constant level for various concentrations. Frequency spectra become narrower with Blebbistatin. Confirmed for N = 2 hearts.