Table 1.
Overview over studies investigating the effect of Blebbistatin onto cardiac electrophysiology.
| Study | Δ APD | N | Conc. [μM] | Species | Preparation |
|---|---|---|---|---|---|
| Fedorov et al. (2007) | Yes | N = 6 | 5–10 | Rabbit | Isolated Heart (Ventr.) |
| No | N = 5 | 5–10 | Rabbit | Wedge Prep. (Atria) | |
| No | N = 5 | 5–10 | Rabbit | Wedge Prep. (SAN) | |
| NA | NA | 5–10 | Rat | Cardiomyocyte (Ventr.) | |
| Dou et al. (2007) | NA | NA | NA | Mouse | Papillary Muscle |
| No | N = 11 | 10 | Mouse | Cardiomyocyte (Ventr.) | |
| Jou et al. (2010) | No | N = 4 | 10 | Zebrafish | Atria |
| No | N = 4 | 10 | Zebrafish | Ventricles | |
| Fenton et al. (2008) | No | N = 1 | 10–15 | Horse | Isolated Heart (Atria) |
| No | N = 1 | 10–15 | Horse | Isolated Heart (Ventr.) | |
| Zhang et al. (2016) | No | N = 1 | 20 | Pig | Isolated Heart (Ventr.) |
| Brack et al. (2013) | Yes | N = 39 | 5 | Rabbit | Isolated Heart (Ventr.) |
| Lee et al. (2019) | Yes | N = 5 | NA | Pig | Isolated Heart (Ventr.) |
| Kappadan et al. | Yes | N = 10 | 3 | Rabbit | Isolated Heart (Ventr.) |
Overall, the findings regarding APD difference (Δ APD) with and without Blebbistatin remain inconclusive and seem to depend on preparations and species.