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. 2020 May 26;11:511. doi: 10.3389/fgene.2020.00511

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Copyright © 2020 Ding, Ma, Zhu, Pu, Zhang, Qian, Zhou, Deng, Guo, Wang and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The flowchart of MICA genotyping and analysis of genetic association with CRC, as well as functional experiments. (A) Flowchart of study activities. (B) Exon-intron organization of MICA gene and primers for PCR sequencing. MICA, the human major histocompatibility complex class I chain-related gene A; P, primer; E, exon; CRC, colorectal cancer; MSI, microsatellite instability; KRAS, Kirsten rat sarcoma oncogene homolog; NRAS, neuroblastoma RAS viral oncogene homolog; BRAF, v-raf murine sarcoma oncogene homolog; MLH1, mutL homolog l; MSH2, mutS homolog 2; MSH6, mutS homolog 6; PMS2, PMS1 homolog 2.