TABLE 1.
The information of genes in the integrated PPI network.
| Gene | Class | Color | Degree | Pathway | Database | PMID |
| GAD2*# | Mutation | Red | 4 | Type I diabetes mellitus* | KEGG | 3003660$ |
| KIF5C | Mutation | Red | 10 | Dopaminergic synapse | KEGG | 18413843$ |
| CCNB1IP1 | Exon | Blue | 2 | Cell cycle | PubMed | 19437480 |
| OFD1 | Methylation | Orange | 7 | Cell cycle | Genecards | 20835237 |
| KIF13B | Mutation | Red | 3 | ∼ | ∼ | 23142292 |
| GTF2IRD1 | Methylation | Orange | 6 | cGMP-PKG signaling pathway | KEGG | 23804703$ |
| PDE3B* | Methylation | Orange | 3 | Hedgehog signaling pathway* | KEGG | 24282571 |
| RPL14 | Mutation | Red | 7 | Ribosome | KEGG | 24824907$ |
| KLF5 | Mutation | red | 13 | Glucose/energy metabolism | Genecards | 25037223 |
| LEP* | Exon | Blue | 10 | JAK-STAT signaling pathway, cell cycle, apoptosis* | KEGG | 25250132 |
| HTR2C* | Mutation | Red | 6 | Calcium signaling pathway* | KEGG | 25323578$ |
| FGFR3* | Methylation | Orange | 37 | MAPK signaling pathway* | KEGG | 25623536 |
| HEXA | Methylation | Orange | 5 | Metabolic pathways | Genecards | 26401073 |
| EXO1 | Mutation | Red | 5 | Mismatch repair | KEGG | 26714599 |
| CRELD2# | Mutation | Red | 2 | ∼ | ∼ | 27392906 |
| KLKB1 | Mutation | Red | 8 | Complement and coagulation cascades | KEGG | 27779706$ |
| LBP* | Exon | Blue | 6 | NF-kappa B signaling pathway* | KEGG | 27876571 |
| GLS2 | Methylation | Orange | 10 | Alanine, aspartate and glutamate metabolism | KEGG | 28007957 |
| SYNE1 | Exon | Blue | 6 | Cell cycle | Genecards | 28058013 |
| EPB41 | Exon | Blue | 128 | Cell cycle | Genecards | 28193906$ |
| DYNC1I1 | Mutation | Red | 10 | Cell cycle | Genecards | 28193906$ |
| GLUL | Methylation | Orange | 8 | Alanine, aspartate and glutamate metabolism | KEGG | 28207045$ |
| ARHGEF15 | Mutation | Red | 4 | GPCR Pathway | Genecards | 29073728 |
| CAPN6# | Mutation | Red | 2 | Apoptosis Pathway | Genecards | 29202800$ |
| MRAS* | Methylation | Orange | 10 | MAPK/PI3K-AKT signaling pathway* | KEGG | 29305742$ |
| PSMA1 | Methylation | Orange | 54 | wnt pathway | Genecards | 29423100 |
| ADAM12 | Mutation | Red | 11 | Insulin growth factor-related pathway | PubMed | 29731694 |
| ASCL2 | Methylation | Orange | 6 | ∼ | ∼ | 29886802 |
| POLG# | Mutation | Red | 2 | Metabolic pathways | Genecards | 30002826 |
| SKAP1* | Methylation | Orange | 7 | Rap1 signaling pathway* | KEGG | 30183087$ |
| TSSC1 | Methylation | Orange | 6 | ∼ | ∼ | 30231249 |
| DAP# | Methylation | Orange | 1 | Apoptosis and autophagy | Genecards | 30552554 |
| MYH10 | Methylation | Orange | 28 | ∼ | ∼ | ∼ |
| RNF7 | Methylation | Orange | 21 | ∼ | ∼ | ∼ |
| SNTB2 | Mutation | Red | 13 | ∼ | ∼ | ∼ |
| MYH2 | Gene_exon | Lightblue | 7 | ∼ | ∼ | ∼ |
| PHOX2A | Methylation | Orange | 5 | ∼ | ∼ | ∼ |
| SFTPA1 | Gene | Green | 5 | ∼ | ∼ | ∼ |
| TRAPPC2 | Methylation | Orange | 5 | ∼ | ∼ | ∼ |
| SLC30A3# | Exon | Blue | 3 | ∼ | ∼ | ∼ |
| EXD3# | Mutation | Red | 2 | ∼ | ∼ | ∼ |
| FAM71E2# | Mutation | Red | 1 | ∼ | ∼ | ∼ |
| OPN4# | Exon | Blue | 1 | ∼ | ∼ | ∼ |
| PMS1 | Mutation | Red | 1 | ∼ | ∼ | ∼ |
| PPP4R4# | Exon | Blue | 1 | ∼ | ∼ | ∼ |
aColumns 1–4 stands for the gene name, corresponding omics data type, color and degree of genes illustrated in the PPI network, respectively. Columns 5 and 6 represent the pathway name and database of gene annotations. Column 7 represents the PMID of the corresponding literature. * Genes and pathways involved in the integrated pathway in Figure 4B. The first column represents all genes that could be mapped to the PPI network. #Genes not illustrated in Figure 4. $Pathway in which the gene located is associated with colon cancer.