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. 2020 May 26;11:441. doi: 10.3389/fphys.2020.00441

FIGURE 1.

FIGURE 1

CXC chemokine ligand 9 (CXCL9) was highly expressed in synovial tissues of patients with rheumatoid arthritis (RA). Osteoarthritis (OA) patients, n = 9; RA patients, n = 22. (A) Differential expressed genes (74 genes) in normal samples and disease samples analyzed in RA-related GSE55457 microarray data of Gene Expression Omnibus (GEO) database. (B) Interaction analysis of differentially expressed genes. (C) H&E staining of the synovial pathological features of patients with OA and RA (×400). (D) RT-qPCR detection of CXCL9 mRNA expression in synovial tissues of patients with OA and RA. (E) Immunohistochemistry of CXCL9 positive protein expression in the synovial tissues of patients with OA and RA (×400). (F) Statistical analysis of panel (E). (G) The level of CXCL9 in synovial tissues of patients with OA and RA detected by ELISA method. Statistical analysis was performed using an independent sample t test. Data were expressed as mean ± standard deviation. *p < 0.05 compared with OA patients.