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. 2020 May 26;11:441. doi: 10.3389/fphys.2020.00441

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Copyright © 2020 Meng and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Silencing of CXC chemokine ligand 9 (CXCL9) repressed the activation, migration, and invasion of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs). RA-FLSs were treated with si-CXCL9-1, si-CXCL9-2, or si-NC. (A) CXCL9 mRNA expression in RA-FLSs detected by RT-qPCR. (B,C) Western blot analysis of protein expression of CXCL9 in RA-FLSs normalized to GAPDH. (D) The levels of IL-1β, IL-6, and IL-8 in RA-FLSs detected by ELISA assay. (E,F) RA-FLS migration ability (×200) detected by transwell assay. (G,H) RA-FLS invasive ability (×200) detected by transwell assay. Data were expressed as mean ± standard deviation and analyzed by one-way ANOVA, followed by Tukey’s post hoc test. *p < 0.05 compared with RA-FLSs treated with si-NC. Cell experiment was repeated three times independently.