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. 2020 May 26;11:441. doi: 10.3389/fphys.2020.00441

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Copyright © 2020 Meng and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXC chemokine ligand 9 (CXCL9) was targeted by miR-320a. (A) miRNAs in mesenchymal stem cell (MSC)-derived exosomes predicted in EVmiRNA database. (B) Upstream regulatory miRNAs of CXCL9 predicted in microRNA database and TargetScan database. (C) Luciferase activity of CXCL9-WT and CXCL9-MUT detected by dual luciferase reporter gene assay; the experiment was repeated three times independently. (D) MiR-320a mRNA level in synovial tissue of patients with osteoarthritis (OA) (n = 9) and patients with rheumatoid arthritis (RA) (n = 22) detected by RT-qPCR. (E) Pearson’s correlation analysis of expression of miR-320a and CXCL9 in synovial tissues of 22 patients with RA. Statistical analysis was performed using an independent sample t test. Data were expressed as mean ± standard deviation. *p < 0.05 compared with the treatment of mimic-NC group or OA patients.