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. 2020 May 26;11:441. doi: 10.3389/fphys.2020.00441

FIGURE 5.

FIGURE 5

Upregulation of miR-320a repressed the activation, migration, and invasion of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLSs) via CXC chemokine ligand 9 (CXCL9). RA-FLSs were treated with mimic-NC + oe-NC, miR-320a mimic + oe-NC, or miR-320a mimic + oe-CXCL9. (A) RT-qPCR detection of miR-320a expression and CXCL9 mRNA expression in RA-FLSs. (B) The levels of IL-1β, IL-6, and IL-8 in RA-FLSs detected by ELISA. (C,D) The migration ability of RA-FLSs (×200) detected by transwell assay. (E,F) The invasive ability of RA-FLSs (×200) detected by transwell assay. Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test. Data were expressed as mean ± standard deviation. *p < 0.05 compared with RA-FLSs treated with mimic-NC + oe-NC; #p < 0.05 compared with RA-FLSs treated with miR-320a mimic + oe-NC. Cell experiment was repeated three times independently.