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. 2020 May 26;11:441. doi: 10.3389/fphys.2020.00441

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Copyright © 2020 Meng and Qiu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mesenchymal stem cell (MSC)-derived exosomal miR-320a decreased the expression of immune factors and the severity of arthritis in collagen-induced arthritis (CIA) mice. CIA mice were injected with phosphate-buffered saline (PBS), Exo-miR-NC, or Exo-miR-320a. (A) Evaluation of arthritis index (AI) values of CIA mice. (B,C) H&E staining of pathological features of CIA mice (×400). (D) The levels of IL-1β, IL-6, and IL-8 measured by ELISA. (E) CXC chemokine ligand 9 (CXCL9) level in CIA mice measured by ELISA. Statistical analysis was performed using one-way ANOVA, followed by Tukey’s post hoc test. Data were expressed as mean ± standard deviation. *p < 0.05 compared with normal mice, and #p < 0.05 compared with CIA mice injected with Exo-miR-NC.