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. 2020 Mar 19;28(6):1479–1493. doi: 10.1016/j.ymthe.2020.03.010

Figure 4.

Figure 4

LINC01234/HNRNPA2B1 Complex Regulates miR-106b-5p Maturation

(A) Heatmaps were drawn to show the differentially expressed miRNAs in LINC01234- or HNRNPA2B1-depleted cells. (B) Venn diagram shows the overlap between LINC01234-regulated miRNAs and HNRNPA2B1-affected miRNAs. (C) qPCR analyses show the changes of pri- and mature miR-106b, miR-17, and miR-362 expression levels after transfection with LINC01234 or HNRNPA2B1 siRNA. (D) Immunoprecipitation of HNRNPA2B1 and qPCR analysis of associated pri-miR-106b. (E) Immunoprecipitation of HNRNPA2B1 and qPCR analysis of associated pri-miR-106b after transfection with LINC01234 siRNA. ∗p < 0.05, ∗∗p < 0.01.