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. 2020 Mar 19;28(6):1479–1493. doi: 10.1016/j.ymthe.2020.03.010

Figure 7.

Figure 7

CRY2 Exerts Tumor-Suppressor Functions via Repressing c-Myc Expression in NSCLC Cells

(A) IHC staining detection of CRY2 in NSCLC tumor and normal tissues. (B) Growth curves show the proliferation ability of the CRY2 overexpression vector or empty vector-transfected cell. (C) Colony formation assays were used to evaluate the colony formation capacity of the CRY2 overexpression vector or empty vector transfected cell. (D) Growth curves show the proliferation ability of CRY2- and LINC01234-overexpressing or -depleted cells. (E) Colony formation assays were used to evaluate the colony formation capacity of CRY2 and LINC01234-overexpressing or -depleted cells. (F) Western blot analysis of c-Myc and CRY2 levels in NSCLC cells overexpressing CRY2. (G) Western blot analysis of c-Myc and CRY2 expression in NSCLC cells with knockdown or overexpression of CRY2 and LINC01234. (H) Kaplan–Meier survival analysis of the association between CRY2 expression level and NSCLC patient overall survival survival. ∗p < 0.05, ∗∗p < 0.01.