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Enzyme Activities and GAG Levels in Neonatal MPS I Mice after Treatment with PS822
(A and B) Enzyme activities (A) increased significantly and GAG storage levels (B) decreased significantly in tissues, including the brain of treated neonatal mice at 11 months post-dosing. Mean ± SEM. ∗p < 0.05 when comparing treated to untreated MPS I mice; ∗∗p < 0.01; ∗∗∗p < 0.0001. One-way ANOVA for multiple comparisons).
