Table 2.

IDUA Enzyme Activities and GAG Levels in the Brain of MPS I Mice after Hydrodynamic Injection of Plasmid Encoding IDUA cDNA under the Control of a Liver-Specific Promoter

	IDUA Enzyme Activity (nmol/h/mg protein)	GAG Levels (μg of GAG/mg of Protein)
Treated MPS I (n = 3)	0.33 ± 0.13	16.4 ± 0.9
Control MPS I (n = 4)	0	23.1 ± 2

The plasmids encoding IDUA cDNA under the control of a liver-specific hAAT promoter were intravenously injected into MPS I mice. Two days later, treated and control mice were perfused and tissues were collected. Enzyme activities and GAG levels in the brain were measured. Data are shown as mean ± standard errors.