Figure 3.
In-Life Assessment of AAV-Mediated GFP Expression in Subretinally Injected Macaques
Confocal scanning laser ophthalmoscopy (SLO) images of macaque eyes that received three extrafoveal subretinal injections (30 mL each) of AAV5, AAV44.9, or AAV44.9 vectors containing hGRK1-GFP (1 × 1012 vg/mL) are shown. Each injection was initiated approximately 25 degrees away from the foveal pit. Images were taken on the day of dosing and at 1, 2, and 6 weeks post-injection. Red lines are superimposed on retinal vasculature to serve as landmarks.