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. 2020 Jan 23;32:101436. doi: 10.1016/j.redox.2020.101436

Table 3.

Statistically significant correlation coefficients for biomarkers of antioxidant status, oxidative damage and clinical outcomes.

First author [reference] Biomarker Sample Clinical outcome r
Vitamins
Lagrange-Puget [7] Vitamin A P/S BMI
FEV1 		+NR
+NR
Madarasi [61] Vitamin A P/S Shwachman-Kulzycki score +0.75
Lagrange-Puget [7] β-carotene P/S BMI
FEV1 		+NR
+NR
Wood [41] β-carotene P/S Monocyte count
Neutrophil count
White cell count		 −0.31a−
0.46a−
0.42a
Lagrange-Puget [7] Lutein P/S BMI +NR
Schupp [57] Lutein P/S Macular pigment optical density +0.76
Lagrange-Puget [7] Lycopene P/S BMI
FEV1 		+NR
+NR
Lagrange-Puget [7] Zeaxanthin P/S FEV1 +NR
Schupp [57] Zeaxanthin P/S Macular pigment optical density +0.80
Madarasi [61] Vitamin C P/S Shwachman-Kulzycki score +0.49
Back [42] Vitamin C P/S Age
FEV1 		−0.77
+0.50
Aris [68] Vitamin D P/S Serum intact parathyroid hormone
Serum osteocalcin
Urinary free deoxypyridinoline		 -NR
+NR
-NR
Hahn [48] Vitamin D P/S Serum calcium
Diaphyseal bone mass		 +0.54
+0.42
Aris [68] 1,25(OH)2D P/S Serum intact parathyroid hormone
Serum osteocalcin
Urinary free deoxypyridinoline		 -NR
+NR
-NR
Back [42] Vitamin E P/S Age
FEV1 		−0.47
+0.46
Lagrange-Puget [7] Vitamin E P/S FEV1 +NR
Oudshoorn [63] Vitamin E P/S Coenzyme Q10 +0.40
Wood [41] Vitamin E P/S Monocyte count
Neutrophil count		 −0.34a−
0.34a
Trace elements
AbdulWahab [69] Zinc P/S BMI
FEV1
FEV1/FVC
FVC		 +NR
+NR
+NR
+NR
Jacob [49] Zinc P/S Age
Retinol binding protein
Vitamin A		 −0.63
+0.64
+0.51
Mocchegiani [47] Zinc P/S Interleukin-2
Weight/age (percentile)
Weight/height deficits (%)		 +0.791
+0.86a
+0.94a
Thiols
Mangione [51] Glutathione Erythrocyte FEV1
FVC		 −0.30
+0.35
Other antioxidants
Lands [73] TEAC P/S BMI
FEV1
Uric acid
Height
Weight
RV/TLC		 +0.47b
+0.43b
+0.49b
+0.39b
+0.50b−
0.42b
Lipid peroxidation
Wood [41] 8-iso-PGF2α P/S P/S β-carotene
P/S vitamin C
P/S vitamin E
Monocyte count
Neutrophil count
White cell count		 −0.42a−
0.43a−
0.37a
+0.37a
+0.31a
+0.31a
Lagrange-Puget [7] MDA P/S Age +NR
Lagrange-Puget [7] TBARS P/S Age
BMI		 +NR
-NR
a

Denotes that both case and control participants were included in the correlation analysis.

b

Denotes that both non-hospitalised and hospitalised participants were included in the correlation analysis. +, statistically significant positive correlation (p ≤ 0.05); -, denotes statistically significant negative correlation (p ≤ 0.05); 8-iso-PGF2α, F2-isoprostane 8-iso-prostaglandin F2α; BMI, body mass index; FEV1, forced expiratory volume in 1 s; MDA, malondialdehyde; NR, correlation coefficient not reported, but there was a statically significant correlation (p ≤ 0.05); P/S, plasma or serum; PICP, serum carboxy-terminal propeptide of type I procollagen; PINP, serum amino-terminal propeptide of type I procollagen; r, correlation coefficient; RV/TLC, residual volume/total lung capacity; TEAC, trolox equivalent antioxidant capacity; TBARS, Thiobarbituric acid reactive substances.