Table 1.
Baseline characteristics of 343 patients with Covid‐19
| Variable | Total n = 343 |
D‐dimer < 2.0 n = 276 |
D‐dimer ≥ 2.0 n = 67 |
P Value |
|---|---|---|---|---|
| Age (IQR), y | 62.0 (48.0, 69.0) | 59.0 (43.5, 68.0) | 70.0 (62.2, 76.0) | <.001 |
| Age > 65, n (%), y | 129 (37.6) | 88 (33.0) | 41 (53.9) | <.001 |
| Female, n (%) | 174 (50.7) | 145 (54.3) | 29 (38.2) | .22 |
| Underlying conditions, n (%) | 120 (35.0) | 79 (29.6) | 41 (53.9) | <.001 |
| Diabetes, n (%) | 47 (13.7) | 31 (11.6) | 16 (21.1) | .007 |
| Hypertension, n (%) | 76 (22.2) | 50 (18.7) | 26 (34.2) | <.001 |
| Coronary heart disease, n (%) | 19 (5.5) | 11 (4.1) | 8 (10.5) | .02 |
| COPD, n (%) | 8 (2.3) | 4 (1.5) | 4 (5.3) | .05 |
| Cancer, n (%) | 9 (2.6) | 5 (1.9) | 4 (5.3) | .08 |
| Stroke history, n (%) | 8 (2.3) | 2 (0.7) | 6 (7.9) | <.001 |
| Chronic kidney disease, n (%) | 4 (1.2) | 4 (1.5) | 0 (0.0) | 1.0 |
| Atrial fibrillation, n (%) | 4 (1.2) | 2 (0.7) | 2 (2.6) | .17 |
| Chronic liver disease, n (%) | 6 (1.7) | 5 (1.9) | 1 (1.3) | 1.0 |
| Routine tests on admission | ||||
| White blood cell, 109/L | 6.66 ± 4.27 | 6.47 ± 4.38 | 7.44 ± 3.72 | .09 |
| Lymphocyte, 109/L (IQR) | 1.36 (0.88, 1.76) | 1.44 (1.03, 1.83) | 0.83 (0.58, 1.24) | <.001 |
| Neutrophil, 109/L (IQR) | 3.68 (2.80, 5.06) | 3.51 (2.71, 4.81) | 4.71 (3.42, 7.32) | <.001 |
| Hemoglobin, 109/L (IQR) | 127 (115, 137) | 127 (117, 139) | 122 (110, 134) | .003 |
| Platelet, 109/L | 242.8 ± 92.3 | 249.3 ± 88.6 | 216 ± 102.7 | .009 |
| CRP, mg/L (IQR) | 3.22 (0.34, 22.5) | 1.69 (0.32, 16.6) | 13.6(1.77, 62.8) | <.001 |
| Direct bilirubin | 4.82 ± 1.46 | 4.83 ± 1.49 | 4.76 ± 1.34 | .74 |
| ALT, U/mL | 28 (16, 49) | 28 (16, 47) | 30.5 (17, 60) | .34 |
| Creatinine, μmol/L (IQR) | 72 (59, 85) | 70 (59, 83) | 76 (64, 99) | .026 |
| Prothrombin time, s (IQR) | 11.7(11.2, 12.3) | 11.6 (11.1, 12.2) | 12.3 (11.6, 13.1) | <.001 |
| aPTT, s | 29.4 ± 4.5 | 29.6 ± 4.3 | 28.8 ± 5.2 | .21 |
| Fibrinogen, g/L (IQR) | 4.1(3.1, 5.1) | 4.1(3.1, 5.1) | 4.3(3.2, 5.6) | .54 |
| D‐dimer, μg/mL (IQR) | 0.54 (0.20, 1.41) | 0.41 (0.15, 0.69) | 4.76 (2.99, 11.9) | <.001 |
| D‐dimer ≤0.5 μg/mL, n (%) | 164 | / | / | / |
| Hospital stay, d | 29 (21, 30) | 29 (22, 30) | 29 (19, 30) | .31 |
| Nonsurvivors, n (%) | 13 (3.8) | 1 (0.4) | 12 (15.8) | <.001 |
Note:Data are mean ± standard deviation, median (IQR), n (%). P values were calculated by t test, Mann‐Whitney U test, chi‐squared test, or Fisher exact test, as appropriate.
Abbreviations: ALT, alanine aminotransferase; aPTT, activated partial thromboplastin time; COPD, chronic obstructive pulmonary disease; CRP, C‐reaction protein; IQR, interquartile range.