Table 1.
Main characteristics of the patients at baseline
| Characteristics | All (n = 26) | Prophylactic Anticoagulation at Admission (n = 8) | Therapeutic Anticoagulation at Admission (n = 18) | P |
|---|---|---|---|---|
| Characteristics at baseline | ||||
| Age (years) | 68 (51.5‐74.5) | 68 (45‐72.7) | 67.5 (53.5‐76.2) | |
| Male sex | 20 (77) | 6 (75) | 14 (78) | |
| Chronic medical condition | ||||
| Active cancer | 0 (0) | 0 (0) | 0 (0) | |
| Previous VTE | 1 (4) | 0 (0) | 1 (6) | |
| Arterial hypertension | 22 (85) | 7 (87) | 15 (83) | |
| Tobacco | 7 (27) | 2 (25) | 5 (28) | |
| Surgery < 3 months | 1 (4) | 0 (0) | 1 (6) | |
| Anticoagulation before admission | 7 (27) | 0 (0) | 7 (39) | .06 |
| Days between symptom onset and admission | 7 (3.2‐8.7) | 7 (6.2‐9.2) | 5.5 (3‐8) | |
| SOFA score | 3 (2‐4.7) | 2.5 (2‐3.2) | 3.5 (3‐5) | .06 |
| Laboratory findings at admission | ||||
| D‐dimers, ng/mL | 1750 (1130‐2850) | 2330 (1495‐3165) | 1750 (1245‐2850) | |
| Fibrinogen, g/L | 7 (6.4‐7.4) | 7.1 (6.9‐8.3) | 6.8 (6.4‐7.3) | |
| Platelets count, G/L | 234 (169‐306) | 261 (159‐316) | 234 (185‐293.5) | |
| CRP, mg/L | 187 (147‐279) | 197 (155‐287) | 177 (147.5‐258.5) | |
| Hematocrit, % | 37.7 (35.9‐41.9) | 41.2 (39.2‐42.3) | 36.5 (34.8‐40.2) | |
| Creatininemia, μmol/L | 79.5 (55.7‐100) | 86 (81.5‐97) | 94.5 (59.7‐103) | .02 |
| Management | ||||
| Worse PaO2/FiO2 ratio | 86.5 (74‐116) | 106 (82‐115) | 78 (70‐117) | |
| Mechanical ventilation | 26 (100) | 8 (100) | 18 (100) | |
| Prone positioning | 16 (62) | 5 (62) | 11 (61) | |
| Venovenous extracorporeal membrane oxygenation | 2 (8) | 1 (12) | 1 (5) | |
| Renal replacement therapy | 4 (15) | 0 (0) | 4 (22) | |
| Vasoconstrictive agent | 23 (88) | 8 (100) | 15 (83) | |
| Antibacterial treatment | 25 (96) | 7 (87) | 18 (100) | |
| Complete duplex ultrasound findings | ||||
| Venous thromboembolism | 18 (69) | 8 (100) | 10 (56) | .03 |
| Superficial | 4 (22) | 2 (25) | 3 (30) | |
| Deep | 14 (78) | 6 (75) | 7 (10) | |
| Bilateral | 10 (55) | 5 (63) | 5 (50) | |
| Outcome | ||||
| ARDS | 21 (81) | 7 (87) | 14 (78) | |
| Pulmonary embolisma | 6 (23) | 0 (0) | 6 (33) | |
| Acute kidney injury | 9 (35) | 2 (25) | 7 (39) | |
| Liver dysfunction | 4 (15) | 1 (12) | 3 (17) | |
| Death | 3 (12) | 1 (12) | 2 (11) | |
Abbreviations: ARDS, acute respiratory distress syndrome; CRP, C‐reactive protein; SAPSII, simplified acute physiology score II; SOFA, sequential organ failure assessment; VTE, venous thromboembolism.
a
Angio‐computed tomography scan in 4 patients and transesophageal echocardiography in 2 patients.