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. 2020 Apr 29;118(11):2641–2655. doi: 10.1016/j.bpj.2020.04.023

Figure 4.

Figure 4

Sensitivity analysis and variation of the unknown parameters. Sensitivity scores for the effect of parameter variation on the concentration of active PLCγ2 were calculated (A). Explicit variation of the parameters with the highest sensitivity scores for the effect on maximal PLCγ2 number and time to reach the maximum for CLEC-2 clustering k−2 (B), CLEC-2 clustering k−1 (C), CLEC-2 clustering k3 (D), CLEC-2 initial number (E), turnover rate of Syk kinases (F), Michaelis constant of Syk kinases (G), forward rate of Syk activation upon SH-2 domain binding to dually phosphorylated hemITAMs (H), Syk initial number (I), reverse rate of LAT phosphorylation (J), turnover rate of Btk (K), Michaelis constant of Btk (L), and LAT initial number (M) are shown. To see this figure in color, go online.