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. 2020 May 1;118(11):2726–2740. doi: 10.1016/j.bpj.2020.04.025

Figure 9.

Figure 9

Model of OAS2-dsRNA interaction. (A) OAS1 recognizes ∼17 bp dsRNA to be activated, and longer dsRNAs are identified indiscriminately. However, OAS2 is only active as a dimer and requires ∼35 bp dsRNA to interact with both catalytically active domains that potentially cause a confirmation change in the dimeric structure catalyzing the 2-5A chains. Short dsRNAs that interact with either of the two active domains are insufficient to activate the full-length dimeric protein. To see this figure in color, go online.