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. 2020 Jan 21;7:100043. doi: 10.1016/j.ynpai.2020.100043

Fig. 1.

Fig. 1

Effects of T cells on the duration of pain in response to Complete Freund’s Adjuvant (CFA). A) Mechanical pain sensitivity was monitored in WT, Rag2−/− and reconstituted Rag2−/− mice treated with saline or CFA (n = 8 mice/group). Repeated measures two-ways ANOVA followed by Bonferonni’s correction (time × genotype interaction, F (32, 264) = 11.4, p < 0.0001. ** = p < 0.01 and *** = p < 0.001 comparing Rag2−/− + CFA vs. Rag2−/− + CD3+ + CFA. B) Difference in time spent in the analgesic-paired chamber before (baseline) and after (test) conditioning in WT and Rag2−/− mice 8 days after intraplantar injection of saline or CFA (n = 8/group). Two-way ANOVA followed by Bonferonni’s correction (CFA × genotype interaction, F(1, 28) = 0.07, p = 0.79; main factor CFA, F(1,28) = 14.3, p = 0.0008). C) Difference in time spent in the analgesic-paired chamber before (baseline) and after (test) conditioning in WT, Rag2−/− and reconstituted Rag2−/− mice 32 days after intraplantar injection of saline or CFA (n = 8/group). One-way ANOVA followed by Bonferonni’s’s correction (F=(4,35) = 6.75, p = 0.0004). Significant statistical difference was indicated by * = p < 0.05, ** = p < 0.01 and *** = p < 0.001. Data are presented as mean ± standard error of the mean.