Fig. 5.

Effects of T cells on peripheral and neuroinflammation in response to CFA. Tnf and Il1b mRNA expression in A,B) ipsilateral paw, C,D) ipsilateral lumbar spinal cord (SC), and E,F) contralateral prefrontal cortex (PFC) at 7 and 38 days after intraplantar injection of CFA or saline (n = 5–8 mice/group). Two-way ANOVA followed by Bonferroni’s correction with CFA as a main factor, A) F(3, 36) = 37.6, P < 0.0001; B) F(4,40) = 8.8.4, P < 0.0001; C) F(3, 46) = 10.5, P < 0.0001; E) F(3, 46) = 5.16, P < 0.0037. Genotype × CFA interactions were not statistically significant for any groups. Significant statistical difference was indicated by * = p < 0.05 and ** = p < 0.01. Data are presented as mean ± standard error of the mean.