Study	Reason for exclusion
Abe 2008	Not a randomised trial
Adelman 2004	Not a randomised trial
Amtmann 2004	Not a randomised trial
Bedlack 2009	Not a randomised trial
Borasio 2001a	Not a randomised trial
Bradley 2001	Not a randomised trial
Carter 2010	Not a randomised trial
Chio 2001	Not a randomised trial
de Carvalho 2001	Not a randomised trial
de Castro‐Costa 1999	Not a randomised trial
Drake 1983	Not a randomised trial
Forshew 2003	Not a randomised trial
Ganzini 1998	Not a randomised trial
Ganzini 1999	Not a randomised trial
Ganzini 2002a	Not a randomised trial
Ganzini 2002b	Not a randomised trial
Hecht 2002	Not a randomised trial
Jensen 2005	Not a randomised trial
Maessen 2010	Not a randomised trial
Mandler 2001	Not a randomised trial
McClelland 2008	Not a randomised trial
Neudert 2001	Not a randomised trial
Newrick 1984	Not a randomised trial
Newrick 1985	Not a randomised trial
O'Brien 1992	Not a randomised trial
Oliver 1996	Not a randomised trial
Oliver 1998	Not a randomised trial
Saunders 1981	Not a randomised trial
Shibata 2003	Not a randomised trial
Tedman 1997	Not a randomised trial
Trail 2003	Not a randomised trial
Weber 2010	A RCT of treatment for cramps in ALS
Winter 2010	Not a randomised trial
Wu 1998	Not a randomised trial