Table 2.

The differences in subcortical volumes between normal controls and MDD patients

Regions (mm3, SD)		MDD (N=20)	HC (N=21)	F	p	FDR p
TICV		1,416.7±109.52	1,395.9±120.48	0.421	0.568	ns
Stem		20.28±1.562	20.90±2.060	3.204	0.640	ns
Thalamus	Lt	7.34±0.573	7.42±0.658	0.450	0.505	ns
Thalamus	Rt	7.01±0.605	7.11±0.654	0.454	0.584	ns
Caudate nucleus	Lt	3.07±0.282	3.17±0.292	1.805	0.635	ns
Caudate nucleus	Rt	3.17±0.254	3.27±0.318	2.256	0.446	ns
Putamen	Lt	4.85±0.474	4.74±0.508	0.299	0.021	ns
Putamen	Rt	4.90±0.444	4.78±0.445	0.434	0.009	ns
Pallidum	Lt	1.56±0.233	1.67±0.241	2.760	0.844	ns
Pallidum	Rt	1.68±0.163	1.70±0.194	0.308	0.419	ns
Hippocamous	Lt	3.71±0.346	3.73±0.446	0.149	0.485	ns
Hippocamous	Rt	3.91±0.279	3.83±0.455	0.184	0.161	ns
Amygdala	Lt	1.20±0.171	1.23±0.178	0.427	0.546	ns
Amygdala	Rt	1.25±0.197	1.24±0.134	0.032	0.671	ns
Accumbens	Lt	0.56±0.871	0.61±0.824	6.135	0.254	ns
Accumbens	Rt	0.43±0.772	0.46±0.071	2.448	0.931	ns

The p values for comparison in age and TICV were obtained by independent t-tests; The group differences in subcortical volumes were tested using analysis of covariance with age, duration of education, and TICV as covariates. The data are expressed as mean±standard deviation (mm³). MDD: major depressive disorder, HC: healthy controls, FDR: false discovery rate by Benjamini and Hochberg, ns: not significant, TICV: total intracranial cavity volume