Figure 1.

Patient diagnosed with a ductal mammary luminal adenocarcinoma metastatic to the liver and initially treated with a CDK4/6 inhibitor (A). Liver contour abnormalities appear a few months after the initiation of a second line of treatment (B) and continue to develop later (C). The patient receives a third line with persisting changes in hepatic morphology (D) and development of partial portal thrombosis (black arrow) and ascites (cross) requiring supportive treatment (E). Finally, the patient will present an episode of haematemesis and the digestive endoscopy will reveal (F) grade III oesophageal varices (white arrows). The patient died a few days later.