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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Exp Hematol. 2020 Mar 30;84:54–66. doi: 10.1016/j.exphem.2020.03.004

Figure 1. Time courses of mortality from 7.9 Gy TBI, hemoglobin depletion, and Fe release in the plasma.

Figure 1.

C57BL/6J mice, 12-14 weeks of age, were exposed to total body 60Co irradiation or sham irradiated (sham). Irradiated mice either received vehicle (Rad + Veh) or captopril (Rad + Cap). A. Kaplan-Meier Curves of the effects of reduced dosage and delayed administration of captopril on survival from TBI. For irradiated groups, n = 16- 20; for the sham irradiated group, n = 8. The percentage of surviving mice are shown. B-D. Blood was obtained at 3, 7, 14, 21 and 30 days post-irradiation for analysis and quantification of RBC (B), reticulocytes (C), and hemoglobin (HBG) (D). Data show means ± SEM, n = 3-5 per group, except for the 30 day time point for radiation + vehicle, which had only one animal (indicated by ‡). * indicates p < 0.05 compared with sham irradiated mice at the same time point. Figures A, B, and C were modified and are reproduced here with permission [24].