Table 2.
Features used by the models in this study compared to those from previous studies.a
Source | Gestational age at prediction | Features, n (for maternal characteristics) or + (used by the model) or – (not used by the model) | |||||||||||||||
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Maternal characteristics | MAPb | PI-UtAc | Bilateral notch | sFlt-1d | PlGFe | PAPP-Af | |||||||||
This study |
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CVRg1 (right PI-UtA) | 24-37 weeks | 2 | – | + | – | + | + | – | ||||||||
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CVR2 (mean PI-UtA) | 24-37 weeks | 2 | – | + | + | + | + | – | ||||||||
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CVR3 (lowest PI-UtA) | 24-37 weeks | 2 | – | + | – | + | + | – | ||||||||
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158-tree random forest | 24-37 weeks | 1 | – | + | + | + | + | – | ||||||||
Previous studies |
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Wright A et al (2019) [26] | 11-13 weeks | 10 | – | + | – | + | + | – | ||||||||
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Wright D et al (2019) [27] | 11-13 weeks | 11 | + | + | – | + | + | – | ||||||||
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Tan MY et al (2018) [25] | 11-13 weeks | 11 | + | + | – | – | + | – | ||||||||
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Sonek J et al (2018) [24] | 11-13 weeks | 10 | – | + | – | – | + | + | ||||||||
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Perales A et al (2017) [23] | 27-28 weeks | 3 | + | – | – | + | + | – | ||||||||
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Nuriyeva G et al (2017) [22] | 11-13 weeks | N/Ah | – | + | – | – | + | + | ||||||||
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O'Gorman N et al (2017) [21] | 11-13 weeks | 11 | + | + | – | – | + | + | ||||||||
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Gallo DM et al (2016) [18] | 19-24 weeks | 11 | + | + | – | + | + | – | ||||||||
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Tsiakkas A et al (2016) [19] | 30-34 weeks | 11 | – | – | – | + | + | – | ||||||||
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Andrietti S et al (2016) [20] | 35-37 weeks | 11 | + | + | – | + | + | – | ||||||||
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O'Gorman N et al (2016) [17] | 11-13 weeks | 10 | + | + | – | – | + | + | ||||||||
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Wright D et al (2015) [16] | 11-13 weeks | 11 | – | – | – | – | – | – |
aModels that showed the best sensitivity and an acceptable specificity in each study.
bMAP: mean arterial pressure.
cPI-UtA: pulsatility index of the uterine artery.
dsFlt-1: soluble fms-like tyrosine kinase receptor-1.
ePlGF: placental growth factor.
fPAPP-A: pregnancy-associated plasma protein-A.
gCVR: classification via regression.
hN/A: not applicable.