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. 2020 May 18;8(5):e15411. doi: 10.2196/15411

Table 2.

Features used by the models in this study compared to those from previous studies.a

Source Gestational age at prediction Features, n (for maternal characteristics) or + (used by the model) or – (not used by the model)


Maternal characteristics MAPb PI-UtAc Bilateral notch sFlt-1d PlGFe PAPP-Af
This study








CVRg1 (right PI-UtA) 24-37 weeks 2 + + +

CVR2 (mean PI-UtA) 24-37 weeks 2 + + + +

CVR3 (lowest PI-UtA) 24-37 weeks 2 + + +

158-tree random forest 24-37 weeks 1 + + + +
Previous studies








Wright A et al (2019) [26] 11-13 weeks 10 + + +

Wright D et al (2019) [27] 11-13 weeks 11 + + + +

Tan MY et al (2018) [25] 11-13 weeks 11 + + +

Sonek J et al (2018) [24] 11-13 weeks 10 + + +

Perales A et al (2017) [23] 27-28 weeks 3 + + +

Nuriyeva G et al (2017) [22] 11-13 weeks N/Ah + + +

O'Gorman N et al (2017) [21] 11-13 weeks 11 + + + +

Gallo DM et al (2016) [18] 19-24 weeks 11 + + + +

Tsiakkas A et al (2016) [19] 30-34 weeks 11 + +

Andrietti S et al (2016) [20] 35-37 weeks 11 + + + +

O'Gorman N et al (2016) [17] 11-13 weeks 10 + + + +

Wright D et al (2015) [16] 11-13 weeks 11

aModels that showed the best sensitivity and an acceptable specificity in each study.

bMAP: mean arterial pressure.

cPI-UtA: pulsatility index of the uterine artery.

dsFlt-1: soluble fms-like tyrosine kinase receptor-1.

ePlGF: placental growth factor.

fPAPP-A: pregnancy-associated plasma protein-A.

gCVR: classification via regression.

hN/A: not applicable.