Table 2. Five-Year Stroke Risks in the Pragmatic and Randomized Clinical Trial–like Samples.
| Sample | % (95% CI) | |||
|---|---|---|---|---|
| Perioperative complications (stroke or death risk at 30 d) | CEA cohort 5-y stroke risk | Initial medical therapy cohort 5-y stroke risk | Risk difference | |
| Pragmatic sample | ||||
| Actual treatment receiveda | 2.5 (2.0 to 3.1) | 7.5 (6.5 to 8.7) | 6.9 (5.8 to 8.1) | NA |
| Emulation of ACST | NA | 5.6 (4.6 to 6.5) | 7.8 (6.3 to 9.3) | –2.3 (–4.0 to –0.3) |
| After accounting for competing risks | NA | 5.4 (4.7 to 6.2) | 6.2 (5.7 to 9.5) | –0.8 (–2.1 to 0.5) |
| RCT-like sample | ||||
| Actual treatment receiveda | 2.4 (1.8 to 3.2) | 6.7 (5.6 to 8.0) | 6.2 (5.1 to 7.6) | NA |
| Emulation of ACST | NA | 5.5 (4.5 to 6.5) | 7.6 (5.7 to 9.5) | –2.1 (–4.4 to –0.2) |
| After accounting for competing risks | NA | 5.3 (4.5 to 6.2) | 6.2 (4.7 to 8.1) | –0.9 (–2.9 to 0.7) |
Abbreviations: ACST, Asymptomatic Carotid Surgery Trial3; CEA, carotid endarterectomy; NA, not applicable; RCT, randomized clinical trial.
a
Obtained from the unadjusted Kaplan-Meier survivor function estimates.