Examples of indications for percutaneous renal mass biopsy of small renal masses. (A) Determining initial management for whom the decision between active surveillance and primary intervention is unclear in a patient who would clearly choose intervention based on a histologic diagnosis. (B) To distinguish rapidly growing benign lesion (ie, oncocytoma) from malignant in a patient on active surveillance whose small renal mass grows > 0.5 cm/year. (C) Determining whether nephronsparing intervention or radical nephrectomy is appropriate in a patient for whom primary intervention is indicated but the benefits of both are unclear. For example, radical nephrectomy may be more justified in the setting of renal cell carcinoma than a benign entity. CBC, complete blood count; CMP, comprehensive metabolic panel; PT/PTT, prothrombin time/partial thromboplastin time; QOL, quality of life.