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. 2020 Jun 2;20:9. doi: 10.1186/s12861-020-00216-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — Effect of pharmacological Notch signaling inhibition and activation on mouse embryo developmental kinetics. Mouse 2.5 dpc embryos were in vitro cultured in the presence of a Notch inhibitor (DAPT) or Notch ligands Jagged1 and Jagged2 until 4.5 dpc. Embryos were observed after 24 h in culture (at 3.5 dpc; a), 36 h in culture (at 4.0 dpc; b) and 48 h in culture (at 4.5 dpc; c) and morphologically evaluated. In vitro culture of a subset of embryos was discontinued at 3.5 dpc or 4.0 dpc to perform transcription analysis. Numbers above bars indicate the number of viable embryos in culture / the number of total embryos. Different letters within the same developmental stage differ significantly, p < 0.05 (Chi-square test). Asterisks (*) indicate the exact p value of the Chi-square test