Figure 1. Pharmacokinetics of oral 17S-RvD1 in rats.

After a single oral dose of 17S-RvD1 in 500μl of corn oil, rats were subjected to multiple blood draws at different time points. Plasma samples underwent SPE and 17S-RvD1 quantified by EIA. 17S-RvD1 plasma concentration increased gradually, peaked at 3 hours reaching a max concentration of 446pg/ml (1.18nM), and went back to baseline within 24 hours (n=3).