Table 2.

GDM association results of the best P + T, LDpred and GraBLD PRSs in South Asian women from the START and UK Biobank.

Method	Consortium	South Asian Women
		START				UK Biobank
		Beta	SE	P-value	AUC	Beta	SE	P-value	AUC
P + T	Mahajan et al., 2014	0.445	0.08	8.7 × 10−9	0.62	0.423	0.14	0.003	0.61
	Scott et al., 2017	0.370	0.07	7.86 × 10−7	0.60	0.280	0.14	0.05	0.57
GraBLD	Mahajan et al., 2014	0.465	0.08	1.8 × 10−9	0.62	0.520	0.14	0.0003	0.64
	Scott et al., 2017	0.317	0.07	1.61 × 10−5	0.59	0.388	0.14	0.006	0.61
LDpred	Mahajan et al., 2014	0.461	0.07	2.18 × 10−9	0.62	0.527	0.14	0.0002	0.65
	Scott et al., 2017	0.347	0.07	4.05 × 10−6	0.59	0.382	0.14	0.006	0.61

Results are from univariate association tests with GDM (LD from 1000 Genomes). Abbreviations: AUC, Area under the curve; GraBLD, Gradient boosted and LD adjusted; NA, Non applicable; P + T, pruning and thresholding; PRS, Polygenic risk score; SE, Standard error; START, South Asian Birth Cohort.