Table 3.
Association results of best PRSs (categories) with GDM in South Asian women from the START and UK Biobank.
| High PRS definition | Reference group | PRS type | South Asian Women | |||||
|---|---|---|---|---|---|---|---|---|
| START | UK Biobank | |||||||
| OR | 95% CI | P value | OR | 95% CI | P value | |||
| Top 25% | Remaining 75% | GraBLD | 2.51 | 1.82–3.47 | 1.75 × 10−8 | 2.66 | 1.51–4.63 | 0.0006 |
| P + T | 2.08 | 1.51–2.87 | 7.44 × 10−6 | 1.80 | 0.99–3.17 | 0.05 | ||
| LDpred | 2.00 | 1.45–2.76 | 2.11 × 10−5 | 2.61 | 1–16–3.60 | 0.01 | ||
| Top 25% | Lowest 25% | GraBLD | 3.40 | 2.25–5.17 | 7.30 × 10−9 | 5.30 | 2.17–15.88 | 0.0008 |
| P + T | 3.09 | 2.10–4.74 | 1.47 × 10−7 | 4.21 | 1.67–12.82 | 0.005 | ||
| LDpred | 3.06 | 2.02–4.69 | 1.77 × 10−7 | 3.59 | 1.53–9.84 | 0.006 | ||
Abbreviations: CI, Confidence interval; PRS, Polygenic risk score; GraBLD, Gradient boosted and LD adjusted; OR, Odds ratio; P + T, Pruning and thresholding; START, South Asian birth cohort.