Table 3.

Number of deaths, annual average crude mortality rate per 1000 person-years, and crude and adjusted annual mortality trend in the cohort of people diagnosed with HIV infection.

	1999–2003		2004–2008		2009–2013		2014–2018		Unadjusted trenda		Adjusted trenda
	N	Rate	N	Rate	N	Rate	N	Rate	RR	p-value	aRR	p-value
All HIV-infected persons	119	33.5	101	26.4	89	21.4	97	20.7	0.97	<0.001	0.95	<0.001
HIV-related mortality	76	21.4	62	16.2	43	10.3	34	7.2	0.93	<0.001	0.92	<0.001
Non-HIV-related mortality	42	12.1	39	10.0	46	11.1	63	13.5	1.01	0.461	1.00	0.913
Cancer (non-AIDS)	9	2.5	17	4.4	19	4.6	21	4.5	1.03	0.213	1.00	0.950
Cardiovascular disease	6	1.7	3	0.8	4	1.0	13	2.8	1.05	0.166	1.02	0.673
Respiratory disease	0	0.0	3	0.8	3	1.0	4	0.9	1.09	0.182	1.04	0.566
Liver disease	0	0.0	3	0.8	5	1.2	3	0.6	1.07	0.262	1.03	0.669
Drug addiction or overdose	15	4.2	5	1.3	4	0.7	4	0.9	0.89	0.012	0.94	0.183
Suicide	4	1.1	3	0.8	3	0.7	4	0.9	0.98	0.698	1.00	0.931
Other external causes	4	1.1	2	0.5	4	1.0	4	0.9	0.97	0.876	0.97	0.666
All other causes	5	1.4	3	0.8	4	1.0	10	2.1	1.05	0.192	1.05	0.300
Diagnosis of ADE	74	71.2	64	54.7	44	36.7	44	36.2	0.95	<0.001	0.94	<0.001
HIV-related mortality	58	55.8	46	39.3	26	21.7	21	17.3	0.92	<0.001	0.91	<0.001
Non-HIV-related mortality	16	15.4	18	15.4	19	15.8	23	18.9	1.01	0.529	1.01	0.595
Not diagnosis of ADE	45	17.9	37	13.9	45	15.1	53	15.2	0.99	0.557	0.98	0.281
HIV-related mortality	18	7.2	16	6.0	17	5.7	13	3.7	0.96	0.080	0.96	0.218
Non-HIV-related mortality	27	10.7	21	7.9	27	9.1	40	11.5	1.01	0.564	0.99	0.691

^aAverage annual trend unadjusted and adjusted for sex, age group (25–34; 35–44, 45–54, 55–64, 65–74), country of birth (Spain or other) and transmission category (history of injecting drug use, men who had sex with men, heterosexual risk exposure, and other risk or unknown).

RR, rate ratio of trend for annual change in mortality.

ADE, AIDS-defining events.