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. 2020 Jun 2;11:2755. doi: 10.1038/s41467-020-16250-4

Fig. 7. FMRP(1–297)-tat restores LTP at the mossy fiber-granule cell synapse of Fmr1 KO mice.

Fig. 7

Shown are plots of mossy fiber-evoked EPSP amplitude and spike firing probability measured in granule cells from Fmr1 KO mice in slices prepared 2 h following tail vein injections. EPSP amplitudes were calculated only for stimuli that were subthreshold to spike discharge. LTP in response to TBS of mossy fibers is restored to near WT levels by prior injection of 1.0 mg/kg FMRP(1–297)-tat in terms of EPSP amplitude (a) (% change in EPSP: 141.0 ± 23.2%, n = 5 cells from 5 mice), firing probability (b) (resting condition 2.0 ± 2.2%, after TBS 36.8 ± 18.4%, n = 5 cells from 5 mice), but with no effect following 0.2 mg/kg FMRP(1–297)-tat injection (c, d) (% change in EPSP: 99.6 ± 10.9%, n = 5 cells from 5 mice) or injection of the tat epitope alone (e, d) (% change in EPSP: 100.4 ± 1.2%, n = 5 cells from 4 mice; no spikes fired in resting condition or after TBS was delivered). Average values are mean ± s.e.m. Source data are provided as a Source Data file.