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. 2020 Jun 2;11:2746. doi: 10.1038/s41467-020-16574-1

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Topology of the bistable TS and the monostable controls. b Molecular implementation. Symbols as described in Fig. 1. c Behavior of TS and control circuits over time in response to two induction schemes: Ara-nothing-AHL-nothing (left) or AHL-nothing-Ara-nothing (right). The percentage of green cells was determined by flow cytometry for four biological replicates (shown are the mean and the s.d.). d Histograms showing representative distributions of the TS cells according to their green fluorescence for the four timepoints indicated in panel c: (i) after Ara induction, (ii) after Ara followed by no inducer, (iii) after Ara-nothing-AHL, and (iv) after Ara-nothing-AHL-nothing. Black: cells below threshold for ‘HIGH’ state (gray line); green: cells in ‘HIGH’ state. Source data are provided as a Source Data file.