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. 2020 Jun 2;11:2746. doi: 10.1038/s41467-020-16574-1

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© The Author(s) 2020, corrected publication 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Topology of the ring oscillator. b Molecular implementation of the CRISPRlator. Symbols as described in Fig. 1. c Montage showing the oscillations of the three fluorescent reporters over time. Bacteria were grown in continuous exponential phase in a microfluidic device for 3 days and imaged every 10 min. Microscopy images (as those enlarged in the zoom-ins) are displayed together in a timeline montage (kymograph). d Quantification of the population-level fluorescence of ~110 cells over time. Oscillations display a period of 10–12 h. Source data are provided as a Source Data file.