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. 2020 May 15;219(6):e201912037. doi: 10.1083/jcb.201912037

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© 2020 Joly et al.

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Figure 7. — Working model of Katanin expression and regulation by cycles of phosphorylation and dephosphorylation during C. elegans development. Schematic representation of Katanin levels and regulation in C. elegans oocytes and embryos. In the top panel, the level of green color represents the amount of Katanin present in oocytes and embryos. Katanin accumulates during oogenesis to reach a maximal level in the oocyte located closed to the spermatheca (-1 oocyte). Katanin levels remain elevated during meiosis I and II but drop after meiosis as a consequence of the activation of the MBK-2 kinase and expression of the MEL-26 E3-ligase subunit. The bottom panel presents a model of the molecular mechanisms regulating Katanin levels and activity. During meiosis, Katanin might cycle between dephosphorylated (Katanin active, green) and phosphorylated (inactive, light blue) states. After meiosis, a large Katanin fraction is targeted for ubiquitin-mediated degradation by the CRL3^MEL-26 E3-ligase while a fraction escaping proteasomal degradation might cycle between phosphorylated and dephosphorylated states.