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. 2020 Jun 2;11:2743. doi: 10.1038/s41467-020-16559-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a CDK phylogenetic tree^4,5,8. b Cell-permeable energy transfer probes used to comprehensively profile CDK engagement in live cells. c Key components for each CDK assay are summarized and described in full in Supplementary Table 2. For simplicity, only CDK11A will be represented in the dendrograms throughout this manuscript. However, both CDK11A and CDK11B isoforms were evaluated.