Fig. 5. Comparison of neutralizing antibody responses for uncoated versus alumina-coated HPV16 L1 vaccine preparations.

Neutralizing antibody responses (day 195 post prime) measured by percent neutralization of HPV16 pseudovirus (n=10) after a 5µg prime/boost immunization with liquid HPV16 L1 capsomeres plus alum (black squares, IC₅₀ = 1600) or equivalent spray-dried formulations (red circles, IC₅₀ = 4300), b 5µg prime/boost immunization with liquid HPV16 L1 capsomeres (black squares, IC₅₀ = 1600) or a single 10µg dose of spray-dried HPV16 L1 capsomeres with 250 coats of alumina (red triangles, red triangles, IC₅₀ = 13,800), and c single 10µg immunization with spray-dried HPV16 L1 capsomeres coated with 250 coats of alumina with (red triangles, IC₅₀ = 12,300) and without (black diamonds, IC₅₀ = 13,800) internal alum.