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. 2020 Jun 2;10:8967. doi: 10.1038/s41598-020-65824-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Large-caliber axons are selectively degraded in mdx mice (a) Fiber diameters (axon plus myelin diameter) in wildtype mice (phrenic: 8.08 μm ± 0.10; XII: 6.76 μm ± 0.11; n = 200 fibers) and mdx mice (phrenic: 7.58 μm ± 0.07; XII: 6.21 μm ± 0.08; n = 300 fibers). Phrenic: p = 1.96 x 10⁻⁵ Two Sample t-test; XII: p = 3.78 x 10⁻⁵ Mann-Whitney U test. (b) Axon diameter values in wildtype mice (phrenic: 5.81 μm ± 0.08; XII: 4.76 μm ± 0.10; n = 200 axons) and mdx mice (phrenic: 5.39 μm ± 0.06; XII: 4.32 μm ± 0.07; n = 300 axons). Phrenic: p = 1.80 ×10⁻⁵ Two Sample t-test; XII: p = 9.52 ×10⁻⁵ Mann-Whitney U test. (c) Distribution of fiber diameters in wildtype mice (phrenic SD: 1.41 μm; XII SD: 1.60 μm) and mdx mice (phrenic SD: 1.18 μm; XII SD: 1.44 μm). (d) Distribution of axon diameters in wildtype mice (phrenic SD: 1.16 μm; XII SD: 1.37 μm) and mdx mice (phrenic SD: 0.10; XII SD: 1.26 μm). (e) Cumulative proportion plots of fiber areas. (f) Cumulative proportion plots of axon areas. (g,h) Brightfield images of nerve cross sections. Black arrows indicate normal-sized axons, while red arrows point to smaller axons. Scale bars represent 10 μm.